期刊
CANCER LETTERS
卷 242, 期 1, 页码 95-103出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.10.046
关键词
protein tyrosine-phosphatase; expression profile; immunohistochemistry; gastric cancer
类别
Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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