期刊
CANCER LETTERS
卷 242, 期 1, 页码 20-27出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.10.030
关键词
angiogenesis; angiopoietin; cyclooxygenase; gastric cancer; hypoxia
类别
We investigated the potential effect of Cyclooxygenase-2 (Cox-2) on hypoxia-induced Angiopoietin-2 (Ang-2) expression in gastric cancer cells. Our results revealed that hypoxia augmented Cox-2 and Ang-2 expressions. Also, the hypoxia-induced Ang-2 could be mimicked by CoCl2 treatment while genestein treatment could partially counteract the hypoxia-induced Ang-2 expression. Celecoxib but not Cox-1 inhibitor sc-560 reversed the hypoxia-induced Ang-2 expression, while this effect could be partially restored by addition of exogenous PGE2. Our findings suggest that the hypoxia-elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1 alpha pathways, while celecoxib could counteract the hypoxia-induced Ang-2 expression. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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