期刊
ONCOGENE
卷 25, 期 46, 页码 6156-6162出版社
SPRINGERNATURE
DOI: 10.1038/sj.onc.1209908
关键词
micro-RNA; micro-RNA processing; Drosha; precursor miRNAs
Micro-RNAs ( miRNAs) are a class of approximately 22-nucleotide non-coding RNAs expressed in multicellular organisms. They are first transcribed in a similar manner to pre-mRNAs. The transcripts then go through a series of processing steps, including endonucleolytic cleavage, nuclear export and a strand selection procedure, to yield the single-stranded mature miRNA products. The transcription and processing of miRNAs determines the abundance and the sequence of mature miRNAs and has important implications for the function of miRNAs.
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