期刊
TETRAHEDRON LETTERS
卷 47, 期 41, 页码 7301-7306出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.08.028
关键词
annosqualine; spiro-isoquinoline alkaloid; iodobenzene diacetate; enamide-phenol coupling; phenoxide formation
The first total synthesis of a spiro-isoquinoline alkaloid, (+/-)-annosqualine, was established by employing an enamidephenol coupling of a 1-methylene-1,2,3,4-tetrahydroisoquinoline derivative with a hypervalent iodine reagent, where the formation of the phenoxide was recognized to be an essential step for the reaction of the phenolic hydroxyl group with the hypervalent iodine reagent leading to the formation of the desired product. (c) 2006 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据