期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 547, 期 1-3, 页码 31-36出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2006.07.040
关键词
mangiferin; polyphenols; iron; superoxide scavenging; cytoprotection
Iron-induced oxidative stress has been implicated in several pathological processes. In the present work we provide evidence for the formation of a mangiferin:Fe(III) complex (2: 1), shown by means of either iron-induced changes in the UV/visible spectrum of mangiferin or by reduction of the anodic current peak in the voltammogram of that compound; we demonstrate, in addition, that the ferric complex is more effective than mangiferin itself in scavenging superoxide radicals generated by pyrogallol autoxidation, as well as in protecting hepatocytes from reactive oxygen species mediated hypoxia/reoxygenation injury. Moreover, we found that the mangiferin:Fe(III) complex reacts more readily with horseradish peroxidase/H2O2 than does mangiferin by itself We postulate that mangiferin could afford protection against iron/reactive oxygen species-mediated pathological processes by means of both iron chelating and iron-stimulated superoxide radical scavenging activity. (c) 2006 Elsevier B.V. All rights reserved.
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