期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 41, 页码 15254-15259出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0601758103
关键词
long-term potentiation; NMDA receptor; knockout; RGS9-2
资金
- Intramural NIH HHS Funding Source: Medline
- NIA NIH HHS [AG17291] Funding Source: Medline
- NINDS NIH HHS [R21 NS047692, NS47692, NS42356, R21 NS042356] Funding Source: Medline
Much research has implicated the striatum in motor learning, but the underlying mechanisms have not been identified. Although NMDA receptor (NMDAR)-dependent long-term potentiation has been observed in the striatum, its involvement in motor learning remains unclear. To examine the role of striatal NMDAR in motor learning, we created striatum-specific NMDAR1 subunit knockout mice, analyzed the striatal anatomy and neuronal morphology of these mice, evaluated their performance on well established motor tasks, and performed electrophysiological recordings to assay striatal NMDAR function and long-term synaptic plasticity. Our results show that deleting the NMDAR1 subunit of the NMDAR specifically in the striatum, which virtually abolished NMDAR-mediated currents, resulted in only small changes in striatal neuronal morphology but severely impaired motor learning and disrupted dorsal striatal long-term potentiation and ventral striatal long-term depression.
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