期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1130, 期 1, 页码 43-53出版社
ELSEVIER
DOI: 10.1016/j.chroma.2006.07.050
关键词
liquid chromatography; 2D chromatography; hydrophilic copolymers; poly(ethylene glycol); poly(vinyl acetate)
A large variety of hydrophilic copolymers is applied indifferent fields of chemical industry including bio, pharma and pharmaceutical applications. For example, poly(ethylene glycol)-poly(vinyl alcohol) graft copolymers that are used as tablet coatings are responsible for the controlled release of the active compounds. These copolymers are produced by grafting of vinyl acetate onto polyethylene glycol (PEG) and subsequent hydrolysis of the poly(ethylene glycol)-poly(vinyl acetate) graft copolymers. The poly(ethylene glycol)-poly(vinyl acetate) copolymers are distributed with regard to molar mass and chemical composition. In addition, they frequently contain the homopolymers polyethylene glycol and polyvinyl acetate. The comprehensive analysis of such complex systems requires hyphenated analytical techniques, including two-dimensional liquid chromatography and combined LC and nuclear magnetic resonance spectroscopy. The development and application of these techniques are discussed in the present paper. (c) 2006 Elsevier B.V. All rights reserved.
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