期刊
NANOTECHNOLOGY
卷 17, 期 19, 页码 4904-4908出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/17/19/020
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In this work, we used co-sputtering of noble metals together with polytetrafluorethylene (PTFE) as a method for producing antibacterial metal/polymer nanocomposite coatings, where the precious metals are only incorporated in a thin surface layer. Moreover, they are finely dispersed as nanoparticles, thus saving additional material and providing a very large effective surface for metal ion release. Nanocomposite films with thickness between 100 and 300 nm were prepared with a wide range of metal filling between 10 and 40%. The antimicrobial effect of the nanocomposite coatings was evaluated by means of two different assays. The bactericidal activity due to silver release from the surface was determined by a modification of conventional disc diffusion methods. Inhibition of bacterial growth on the coated surface was investigated through a modified proliferation assay. Staphylococcus aureus and S. epidermidis were used as test bacteria, as these species commonly cause infections associated with medical polymer devices. The antibacterial efficiency of the coatings against different bacteria was demonstrated at extremely small noble metal consumption: Au: similar to 1 mg m(-2) and Ag: similar to 0.1 g m(-2). The maximum ability for having an antibacterial effect was shown by the Ag-Au/PTFE nanocomposite, followed by the Ag/PTFE nanocomposite.
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