期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 14, 期 20, 页码 6971-6978出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2006.06.027
关键词
cationic peptides; fluorine; antimicrobial activity; peptide design
The effect of introducing fluorine atoms or trifluoromethyl groups in either the peptidic chain or the C-terminal end of cationic pentapeptides is reported. Three series of amide and ester peptides were synthesised and their antimicrobial properties evaluated. An enhanced activity was found in those derivatives whose structure contained fluorine, suggesting an increase in their hydrophobicity. (c) 2006 Elsevier Ltd. All rights reserved.
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