期刊
VIBRATIONAL SPECTROSCOPY
卷 42, 期 1, 页码 98-117出版社
ELSEVIER
DOI: 10.1016/j.vibspec.2006.01.004
关键词
Raman spectroscopy; IR spectroscopy; VCD spectroscopy; peptide structure; coupled oscillator model
Over the last 40 years the theoretical basis has been developed for using vibrational spectroscopy as a tool for peptide and protein structure analysis. In spite of these efforts it is still considered to be a low-resolution technique, which cannot compete with NMR and X-ray crystallography. However, experimental and computational developments over the last 10 years have provided tools which make vibrational spectroscopy a much more powerful technique. This review focuses mostly, though not exclusively, on the use of the amide I mode for the structure analysis of polypeptides. It evaluates the physical basis of a variety of theoretical and experimental concepts and argues that only a combination of different techniques and spectroscopies can advance the field towards a more precise determination of dihedral angles in even highly heterogeneous polypeptides. (C) 2006 Elsevier B.V. All rights reserved.
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