期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 49, 期 21, 页码 6143-6146出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm060792t
关键词
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The androgen receptor is a member of the extended family of nuclear receptors and is widely distributed throughout the body. Androgen therapy is used to compensate for low levels of the natural hormones testosterone (T) and dihydrotestosterone and consists of administration of T, prodrugs thereof, or synthetic androgens. However, currently available androgens have many drawbacks. We identified 6-dialkylamino-4-trifluoromethylquinolin-2(1H)-ones as orally available tissue-selective androgen receptor modulators.
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