期刊
NEURON
卷 52, 期 2, 页码 371-381出版社
CELL PRESS
DOI: 10.1016/j.neuron.2006.08.009
关键词
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资金
- NIDCD NIH HHS [R03 DC005708-02, R03 DC005708, R03 DC005708-01A1, R03 DC005708-03, 5R03DC005708] Funding Source: Medline
- NINDS NIH HHS [5R01NS010413] Funding Source: Medline
We tested the involvement of cognition in adult experience-dependent neuroplasticity using primate cortical implants. In a prior study, learning an operant sensory discrimination increased cortical excitability and target selectivity. Here, the prior task was separated into three behavioral phases. First, naive animals were exposed to stimulus-reward pairings from the prior study. These yoked animals did not have to discriminate to be rewarded and did not learn the discrimination. The plasticity observed in the prior study did not occur. Second, the animals were classically conditioned to discriminate the same stimuli in a simplified format. Learning was accompanied by increased sensory response strength and an increased range of sensory inputs eliciting responses. The third study recreated the original operant discrimination, and selectivity for task targets increased. These studies demonstrate that cognitive association between sensory stimuli and reinforcers accompanies adult experience-dependent cortical plasticity and suggest that selectivity in representation and action are linked.
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