期刊
BRAIN RESEARCH
卷 1116, 期 -, 页码 120-126出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.07.001
关键词
extinction; self-administration; cocaine; LTP; hippocampus
Drug addiction may involve learning and memory processes requiring the participation. of hippocampal formation. One of the best studied examples of hippocampal synaptic plasticity is the long-term potentiation (LTP) which usually occurs when hippocampal synapses are stimulated with high-frequency stimulation. The aim of this work has been to study the effect of extinction of cocaine self- administration behavior on synaptic plasticity in rat hippocampal slices. LTP was induced using a tetanization paradigm consisting of a single train of high-frequency (100 Hz) stimulation for one second. This tetanization protocol evoked a greater and more perdurable LTP in slices obtained after 10 days of extinction of cocaine self-administration (1 mg/kg/injection) than that elicited in slices from saline self-administering (0.9% NaCl) animals. In addition, this LTP facilitation in animals which have followed the cocaine self-administration extinction protocol was very similar to that obtained in slices from cocaine self-administering animals. These results suggest that chronic cocaine self-administration induces enduring neuroadaptive changes in hippocampal synaptic plasticity which last even after the extinction of this: behavior and that they may be involved in cocaine dependence. (c) 2006 Elsevier B.V. All rights reserved.
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