DMAP catalyzed reaction of β-ketoesters and dimethyl acetylenedicarboxylate:: efficient synthesis of polysubstituted benzenes and biaryls

A DMAP catalyzed tandem addition-cyclization-dehydration sequence involving dimethyl acetylenedicarboxylate and beta-ketoesters leading to polysubstituted benzene/biaryl derivatives is presented. (c) 2006 Elsevier Ltd. All rights reserved.