期刊
LIFE SCIENCES
卷 79, 期 22, 页码 2128-2134出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2006.07.006
关键词
neonate; chronic diseases programming; kidney; hypertension; stereology
To investigate the early renal alterations due to severe maternal protein restriction (MPR) Wistar dams received 23% (normal protein, NP) or 5% (low. protein, LP) chow during gestation and lactation periods. In NP offspring at birth, the cortex-to-medulla (C/M ratio was 35% greater in female than in male offspring and the mature/immature glomeruli ratio was lower in both sexes of LP offspring than in the matched NP ones (by 20%). At birth and at weaning the kidney of the LP offspring showed fewer glomeruli (40% less) than the age-matched NP offspring. The NP female offspring had almost 20% fewer glomeruli than the matched male offspring. At weaning, the number of glomeruli was positively correlated with BM at birth (R=0.86; P < 0.001). The effects of gender and maternal protein restriction, both individually and overall, based on biometrical and: stereological parameters were: day 1, MPR largely responsible for the majority of alterations observed in LP groups, however gender influenced C/M ratio; day 2 1, MPR, and gender interacted and modified the number of glomeruli per kidney. The early adverse of MPR effect on renal development is disproportionate between mature and immature glomeruli at birth leading to fewer glomeruli at weaning. This supports epidemiological data in humans underlying why fetuses with low birth weight carry an increased risk of mortality from chronic diseases in adulthood, including hypertension. (c) 2006 Elsevier Inc. All rights reserved.h
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