期刊
ORGANIC LETTERS
卷 8, 期 22, 页码 5165-5168出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol0622211
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资金
- Intramural NIH HHS [Z01 BC007363-13] Funding Source: Medline
- NCI NIH HHS [N01 CO 12400, N01CO12400] Funding Source: Medline
Replacing the Pro6 in the p6(Gag)-derived 9-mer P-E-P-T-A-(P) under bar -P-E-E with N-substituted glycine (NSG) residues is problematic. However, incorporation of hydrazone amides (peptoid hydrazones) can be readily achieved in library fashion. Furthermore, reduction of these hydrazones to N-substituted peptoid hydrazides affords a facile route to library diversification. This approach is demonstrated by application to Tsg101-binding compounds designed as potential HIV budding antagonists.
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