Cytotoxic constituents from the formosan soft coral Clavularia inflata var. luzoniana

Three new cytotoxic dolabellane diterpenes, 1-3, three new aromandendrane sesquiterpenoids, 4-6, a new sesquiterpene, 7 ( having a new carbon skeleton), and a new cytotoxic xenicane diterpene, 8, were isolated from the methylene chloride solubles of the Formosan soft coral Clavularia inflata var. luzoniana. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.