期刊
JOURNAL OF NATURAL PRODUCTS
卷 69, 期 10, 页码 1485-1487出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0503698
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Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.
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