4.7 Article

A short water-soluble self-assembling peptide forms amyloid-like fibrils

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CHEMICAL COMMUNICATIONS
卷 -, 期 40, 页码 4230-4232

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ROYAL SOC CHEMISTRY
DOI: 10.1039/b607657b

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A water-soluble tripeptide Val-Ile-Ala (VIA) 1, bearing sequence identity with the C-terminal portion of the Alzheimer A beta-peptide (A beta(40-42)), self-assembles, in crystalline form, to produce an intermolecularly hydrogen bonded supramolecular beta-sheet structure which self-associates to form straight, unbranched nanofibrils exhibiting amyloid-like behavior; in contrast, the synthetic tripeptide Ala-Val-Ile (AVI) 2 self-assembles to produce a beta-sheet structure that forms branched nanofibrils which do not show any characteristic features of amyloid-like fibrils.

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