期刊
CANCER LETTERS
卷 242, 期 2, 页码 141-150出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.12.032
关键词
Sprouty; cancer; tumour suppressor; tumour marker; Ras/Erk pathway; gene deregulation
类别
资金
- Medical Research Council [G0100100] Funding Source: Medline
- MRC [G0100100] Funding Source: UKRI
- Medical Research Council [G0100100] Funding Source: researchfish
The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据