A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

A robust method has been developed to couple a wide variety of pyridin-2-ones and aryl halides. This C-N bond forming reaction makes use of catalytic copper(I) iodide and the ligand 8-hydroxyquinoline. These conditions tolerate a wide degree of functionality on both the aryl halide and pyridin-2-one reactants and have resulted in numerous examples being synthesized. (c) 2006 Elsevier Ltd. All rights reserved.