期刊
ONCOGENE
卷 25, 期 51, 页码 6868-6886出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1209935
关键词
NF-kappaB; hormone; nuclear receptor; glucocorticoid receptor; estrogen receptor; PPAR
A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor kappa B (NF-kappa B), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-kappa B and the biological relevance of this crosstalk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-kappa B-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据