期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 147, 期 2-3, 页码 115-126出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2006.01.002
关键词
fMRI; thalamus; anterior cingulate cortex; language; neuromiaging
资金
- NIMH NIH HHS [R01 MH 52886, R01 MH 43775-14, R01 MH 60504] Funding Source: Medline
The recall of an object from features is a specific operation in semantic memory in which the thalamus and pre-supplementary motor area (pre-SMA) are integrally involved. Other higher-order semantic cortices are also likely to be involved. We used the object-recall-from-features paradigm, with more sensitive scanning techniques and larger sample size, to replicate and extend our previous results. Eighteen right-handed healthy participants performed an object-recall task and an association semantic task, while undergoing functional magnetic resonance imaging. During object-recall, subjects determined whether words pairs describing object features combined to recall an object; during the association task they decided if two words were related. Of brain areas specifically involved in object recall, in addition to the thalamus and pre-SMA, other regions included the left dorsolateral prefrontal cortex, inferior parietal lobule, and middle temporal gyrus, and bilateral rostral anterior cingulate and inferior frontal gyri. These regions are involved in semantic processing, verbal working memory and response-conflict detection and monitoring. The thalamus likely helps to coordinate activity of these different brain areas. Understanding the circuit that normally mediates this process is relevant for schizophrenia, where many regions in this circuit are functionally abnormal and semantic memory is impaired. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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