期刊
FEBS LETTERS
卷 580, 期 25, 页码 5880-5884出版社
WILEY
DOI: 10.1016/j.febslet.2006.09.054
关键词
Stat3; IL-6; oncostatin M; transcription; serine phosphorylation
资金
- NIGMS NIH HHS [GM61652] Funding Source: Medline
To achieve maximal transcriptional activity in response to gp130 cytokines, Serine-727 (Ser-727) of Stat3 is phosphorylated. Ser-727 resides in the LPMSP motif, the only conserved sequence among the transcription activation domains of several STATs. We show here that in addition to Ser-727, other residues in this LPMSP motif are also required for Stat3 activity in response to cytokine signaling through regulation of Ser-727 phosphorylation and recruitment of the transcription co-activator CBP/p300 to the promoters of Stat3-target genes for transcription activation. Hence, we have demonstrated a critical role for the whole conserved LPMSP motif in JAK-STAT signaling. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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