期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 80, 期 5, 页码 1013-1017出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0306151
关键词
unintegrated DNA; HIV-1; integrase inhibitors; vaccine; gene therapy
Following retroviral infection of cells, not only is the proviral DNA integrated into the host genome, but there is also an accumulation of unintegrated extrachromosomal DNA (E-DNA), both linear and circular. Although the integrated DNA is responsible for the production of viral proteins and new viral progeny, the role of E-DNA has remained uncertain. Several reports have shown that E-DNA is transcriptionally active producing both RNA, as well as viral proteins and that circular E-DNA can persist in nondividing cells, raising questions regarding the potential consequences of this reservoir. Furthermore, integrase inhibitors, presently in clinical trials, shifts the balance of proviral DNA to the E-DNA form. This review is focused on recent work in this field with an emphasis on exploring the potential role of E-DNA in both pathogenesis of retroviral infections, especially HIV-1, and as a tool to deliver and express genes. J. Leukoc. Biol. 80: 1013-1017; 2006.
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