期刊
NATURE GENETICS
卷 38, 期 11, 页码 1289-1297出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1901
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资金
- NCI NIH HHS [CA089393] Funding Source: Medline
- NHGRI NIH HHS [R01 HG004069-01, R01 HG004069] Funding Source: Medline
- NIDDK NIH HHS [DK074967] Funding Source: Medline
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation, particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer.
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