期刊
NATURE MEDICINE
卷 12, 期 11, 页码 1278-1285出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1498
关键词
-
资金
- NHLBI NIH HHS [HL63290] Funding Source: Medline
Brain hemorrhage is a serious complication of tissue plasminogen activator (tPA) therapy for ischemic stroke. Here we report that activated protein C (APC), a plasma serine protease with systemic anticoagulant, anti- inflammatory and antiapoptotic activities, and direct vasculoprotective and neuroprotective activities, blocks tPA- mediated brain hemorrhage after transient brain ischemia and embolic stroke in rodents. We show that APC inhibits a pro- hemorrhagic tPA- induced, NF-kappa B-dependent matrix metalloproteinase-9 pathway in ischemic brain endothelium in vivo and in vitro by acting through protease-activated receptor 1. The present findings suggest that APC may improve thrombolytic therapy for stroke, in part, by reducing tPA- mediated hemorrhage.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据