期刊
PEPTIDES
卷 27, 期 11, 页码 2993-2999出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2006.05.023
关键词
natriuresis; natriuretic peptides; cGMP; pulmonary hypertension; renal function
We examined the mechanisms of renal resistance to atrial and brain natriuretic peptides (ANP and BNP) in pulmonary hypertension (PH). Compared to eight controls, nine PH patients showed a reduced ability to excrete an acute sodium load despite increased circulating ANP, BNP and cyclic guanosine monophosphate (cGMP), their second messenger. Patients' reduced urinary cGMP/BNP and natriuresis/urinary cGMP ratios demonstrated impaired generation of and reduced renal response to cGMP, respectively. Therefore, PH patients hyporesponsiveness to cardiac natriuretic peptides is likely located both upstream and downstream cGMP generation. Natriuretic peptide signalling pathway disruptions might be accessible to therapy. (c) 2006 Elsevier Inc. All rights reserved.
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