期刊
JOURNAL OF COMPARATIVE PATHOLOGY
卷 135, 期 4, 页码 217-225出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2006.07.003
关键词
amyloidosis; arteritis; cetacean; dolphin; nodular hyperplasia; thyroid gland; Tursiops truncatus
Fresh thyroid glands (n = 60) from Atlantic bottlenose dolphins that died after stranding along the Texas coast between 1991 and 2005 were examined. Organ weight ranged from 11 g in a neonate (length 109 cm) to 58 g in a large (249 cm) male. More typical weights were 25-45 g (mean = 30.6 g). Glands tended to be larger in pregnant and lactating females (mean 37.4 g; n = 5) than in non-pregnant animals of comparable size. In infancy, the gland tended to be compact, relatively homogeneous, and sometimes partly lobular, but with advancing age it became more lobular, the lobules being defined by fibrous bands. In one 8-year-old female (233 cm), and in a large male (295 cm) aged > 25 years the gland was represented by a cluster of lobules. Lobulation was not necessarily accompanied by increased weight, distinguishing it from hyperplasia. With age, variation in follicle size and colloid density, tended to increase. Two animals (3%) had adenomas and five (8%) had discrete hyperplastic nodules, not to be confused with lobulation. Five (8%) had macroscopically identifiable colloid-filled cysts (1-4 mm in diameter). Nine animals (15%) had squamous cysts (4-15 mm) containing creamy white fluid. Other abnormalities included patchy or diffuse interstitial fibrosis (six cases, 10%) amyloidosis (two cases), thyroiditis (one case) and vasculitis (one case). No malignant neoplasms were found. Cells presumed to be C cells (light cells, parafollicular cells) were identified immunohistochemically with synaptophysin antibody. (c) 2006 Elsevier Ltd. All rights reserved.
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