期刊
ARCHIVES OF NEUROLOGY
卷 63, 期 11, 页码 1627-1631出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archneur.63.11.1627
关键词
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资金
- Medical Research Council [G9724461, MC_U105559861] Funding Source: researchfish
- MRC [MC_U105559861, G9724461] Funding Source: UKRI
- Medical Research Council [MC_U105559861, G9724461] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Objective: To assess the clinical course and prognosis in patients with behavioral-variant frontotemporal dementia (FTD) lacking evidence of brain atrophy on magnetic resonance imaging (MRI). Design: Patients were enrolled into this prospective cohort study over a period of 15 years; cognitive status, duration of symptoms, and behavioral indexes were recorded. Brain MRIs were rated using a standardized scale. Setting: Regional early-onset dementia clinic. Participants: Thirty-one participants diagnosed clinically with behavioral-variant FTD. Intervention: Rating of MRIs. Main Outcome Measures: Death or institutionalization after a minimum of 3 years' follow-up indicated poor prognosis, while the ability to live independently was regarded as a good prognosis for the purpose of survival (Kaplan-Meier) and discriminant function analysis. Results: Patients with normal or borderline MRI findings (n = 15) showed significantly longer survival to institutionalization or death than those (n = 16) with definite frontotemporal atrophy (mean +/- SE, 9.3 +/- 1.7 years vs 3.0 +/- 0.7 years; P < .01). Using groups defined by 3-year outcome (good or bad prognosis), cerebral atrophy predicted poor outcome while age, symptom duration, cognitive performance, behavioral impairment, and overall disability at baseline did not. Conclusions: Patients with FTD with normal MRI results follow a more benign course than cases with atrophy at presentation. The substrate of the behavioral symptoms in such cases may differ from the neurodegenerative pathological features typically associated with FTD.
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