期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 41, 期 5, 页码 914-917出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.yjmcc.2006.08.001
关键词
early afterdepolarization; arrhythmia; nutrition; diet; omega 3 fatty acids; fish oil; membrane potential; voltage clamp
Fish oil reduces sudden cardiac death in post myocardial infarction patients. Life-threatening arrhythmias in heart failure are associated with repolarization abnormalities leading to EAD(1) formation. We examined the effects of incorporated fish oil omega 3-PUFAs2 on EAD formation in pig myocytes. Pigs were fed a diet rich in fish oil or sunflower oil (control) for 8 weeks. Myocytes were isolated by enzymatic dissociation and patch-clamped. Susceptibility to EAD formation was tested using E4031 (5 mu M), a blocker of I-Kr. The fish oil diet in pigs resulted in increased incorporation of omega 3-PUFAs in the sarcolemma of the myocytes compared to the control diet and caused a reduced occurrence of E4031-induced EADs in pig myocytes. A shorter action potential, a reduced action potential prolongation in response to E-4031 and a reduced reactivation of I-Ca,I-L by omega 3-PUFAs may explain the observed reduction in EADs. A diet rich in fish oil protects against EAD formation. (c) 2006 Elsevier Inc. All rights reserved.
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