期刊
NEUROPSYCHOLOGY
卷 20, 期 6, 页码 633-644出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0894-4105.20.6.633
关键词
prospective memory; apolipoprotein E; Alzheimer's disease
资金
- PHS HHS [P01AGO3991, P50AGO5681] Funding Source: Medline
The present study examined whether prospective memory performance discriminates healthy aging from very mild dementia of the Alzheimer type (DAT) and individuals at risk for DAT because of the presence of the apolipoprotein E (ApoE) epsilon 4 allele. Four groups (young subjects, young-old control subjects, old-old control subjects, and subjects with very mild DAT) engaged in an event-based prospective memory task wherein they responded to a specific word embedded in a general knowledge test. Results indicated that prospective memory performance was clearly impaired in the very mild DAT group relative to the healthy older control groups. Moreover, prospective memory performance appears to capture unique variance in discriminating these 2 groups above and beyond standard retrospective memory tests. However, prospective memory was not affected by ApoE status in the young-old control group and, contrary to predictions, the epsilon 4+ old-old control subjects showed better performance than did the epsilon 4- subjects. In contrast to the healthy individuals, in the very mild DAT group, epsilon 4+ subjects showed deficits in performance relative to the epsilon 4- subjects. Discussion focuses on prospective memory as a cognitive indicator of early stage DAT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据