New nematicidal azaphilones from the aquatic fungus Pseudohalonectria adversaria YMF1.01019

Two new azaphilone metabolites, named pseudohalonectrin A (1) and B (2), were isolated from the culture of the aquatic fungus Pseudohalonectria adversaria YMF1.01019, originally separated from submerged wood in Yunnan Province, China. Pseudohalonectrin A and B were assessed for their nematicidal activity against the pine wood nematode Bursaphelenchus xylophilus and their structures were defined after spectral analysis. This is the first report of secondary metabolites from any member of the genus Pseudohalonectria.