期刊
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
卷 16, 期 11, 页码 2396-2402出版社
IOP PUBLISHING LTD
DOI: 10.1088/0960-1317/16/11/021
关键词
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We demonstrate a non-contact pumping mechanism for the manipulation of aqueous solutions within microfluidic devices. The method utilizes multi-layer soft lithography techniques to integrate a thin polydimethylsiloxane (PDMS) membrane that acts as a diffusion medium for regulated air pressure and a vacuum. Pressurized microchannels filter air through the PDMS membrane due to its high gas permeability causing a pressure difference in the liquid channel and generating flow. Likewise, a vacuum can be applied to pull air through the membrane allowing the filling of dead-end channels and the removal of bubbles. Flow rates vary according to applied pressure/vacuum, membrane thickness and diffusion area. A gas permeation pump is an inexpensive alternative to other micropumps. The pump is easily integrated with highly arrayed multi-channel/chamber applications for micro-total analysis systems, fluid metering and dispensing, and drug delivery. Flow rates of 200 nl min(-1) have been achieved using this technique. Successful localized fluid turning at intersections, fluid metering and filling of dead-end chambers were also demonstrated.
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