期刊
PHARMACOGENOMICS JOURNAL
卷 6, 期 6, 页码 401-412出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.tpj.6500390
关键词
CYP2A6; CYP2A7; deletion allele; genetic polymorphism
Human cytochrome P450 (CYP) 2A6 metabolizes nicotine to cotinine. Genetic polymorphisms of CYP2A6 contribute to the interindividual variability of nicotine metabolism. We encountered some subjects possessing two copies of the CYP2A6 gene, although they were genotyped as heterozygotes of the CYP2A6*4A allele ( entire CYP2A6 gene deleted allele). From the subjects, we found CYP2A7 polymorphic alleles (CYP2A7*1B, CYP2A7*1C, and CYP2A7*1D) in which the sequences in the 3'-flanking region were converted to the corresponding CYP2A6 sequences, being confused with the CYP2A6*4A. These allele frequencies in European-Americans (n = 187) were 1.3, 2.1, 0.3%, respectively, but these were very rare in African-Americans (n = 176), Japanese (n = 184), and Koreans ( n 209). By an improved genotyping method, the allele frequency of CYP2A6*4A of 3.7% in European-Americans was corrected to 0%. The comprehensible and reliable genotyping method developed in this study would be useful to evaluate associations between the genotype and phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据