期刊
RESUSCITATION
卷 71, 期 2, 页码 248-253出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.resuscitation.2006.02.023
关键词
cardiac arrest; blood flow; ventricular fibrillation; coronary perfusion pressure
There is growing evidence that microcirculatory blood flow is the ultimate determinant of the outcome in circulatory shock states. We therefore examined changes in the microcirculation accompanying the most severe form of circulatory failure, namely cardiac arrest and the effects of subsequent cardiopulmonary resuscitation. Ventricular fibrillation was electrically induced in nine pigs and untreated for 5 min prior to beginning closed chest cardiac compression and attempting electrical defibrillation. Orthogonal polarization spectral. imaging was utilized for visualization of the sublingual. microcirculation at baseline, 0.5, 1, 3 and 5 min after onset of ventricular fibrillation and at 1 and 5 min after start of chest compression. Images were also obtained 1 and 5 min after restoration of spontaneous circulation. Microvascular flow was graded from 0 (no flow) to 3 (normal flow). Aortic and right atrial pressures were measured and coronary perfusion pressure was computed continuously. Microcirculatory blood flow decreased to Less than one-fourth within 0.5 min after inducing ventricular fibrillation. Precordial compression partially restored microvascular flow in each animal. In animals that were successfully resuscitated, microvascular flow was significantly greater after 1 and 5 min of chest compression than in animals with failed resuscitation attempts. Microvascular blood flow was highly correlated with coronary perfusion pressure (r = 0.82, p < 0.01). Microvascular blood flow in the sublingual mucosa is therefore closely related to coronary perfusion pressure during cardiopulmonary resuscitation and both are predictive of outcome. (c) 2006 Elsevier Ireland Ltd. ALL rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据