期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 26, 期 21, 页码 8191-8201出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00242-06
关键词
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资金
- NCI NIH HHS [CA34936, P01 CA034936, P30 CA016672, CA16672] Funding Source: Medline
MicroRNAs are an extensive family of similar to 22-nucleotide-long noncoding RNAs expressed in a wide range of eukaryotes, including humans, and they are important in development and disease. We found that microRNA Mir-17-5p has extensive complementarity to the mRNA of AIB1 (named for amplified in breast cancer 1). Cell culture experiments showed that AIB1 expression was downregulated by Mir-17-5p, primarily through translational inhibition. Expression of Mir-17-5p was low in breast cancer cell lines. We also found that downregulation of AIB1 by Mir-17-5p resulted in decreased estrogen receptor-mediated, as well as estrogen receptor-independent, gene expression and decreased proliferation of breast cancer cells. Mir-17-5p also completely abrogated the insulin-like growth factor 1-mediated, anchorage-independent growth of breast cancer cells. Our results reveal that Mir-17-5p has a role as a tumor suppressor in breast cancer cells.
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