期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 80, 期 5, 页码 984-993出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0306154
关键词
plasmacytoid dendritic cells; innate immunity; adaptive immunity; immune therapy; vaccination; primary infection; virus
Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this depends on the viral stimulus. The migration and distribution of pDC into lymphoid organs, driven by chemokine interactions with their ligands, determines interaction with different cell types. In HIV infection, IFN production in vitro is impaired during primary infection and later in association with opportunistic infections. Circulating pDC numbers are decreased in parallel. These parameters may he used to help assess the prognosis of the disease and to monitor treatment. J. Leukoc. Biol. 80: 984-993; 2006.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据