期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 32, 期 10, 页码 1199-1206出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040600751886
关键词
simvastatin; local delivery; osteogenesis; granules; gel; in vitro release
Simvastatin (SVS), a cholesterol-lowering drug, has been shown to stimulate bone formation. This study deals with the design and in vitro evaluation of local delivery systems for simvastatin. They are intended to treat bony defects resulting from periodontitis or to induce osteogenesis around the titanium implants. Granules and gels were formulated using bioerodible/biocompatible polymers, namely hydroxypropylmethyl cellulose ( H), sodium carboxymethyl cellulose ( C), and chitosan (Ch). The in vitro release profiles and kinetics were evaluated and the swelling and/or erosion was monitored. Differential scanning calorimetry (DSC) and infrared (IR) were used to detect any SVS/polymer interactions that may affect drug release. The results revealed variable extents of controlled drug release from the designed formulae depending on the polymer nature. About 50% cumulative SVS was released from both H granules and gel formulae within 24 h and similar to 66% and similar to 88% from C granules and gel, respectively. Ch formulae exhibited similar to 50% release from granules and similar to 30% from gel.
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