期刊
BRAIN & DEVELOPMENT
卷 28, 期 10, 页码 663-667出版社
ELSEVIER
DOI: 10.1016/j.braindev.2006.05.001
关键词
Juvenile Alexander disease; novel GFAP mutation; thyrotropin releasing hormone (TRH) therapy; cerebellar ataxia
Alexander disease is a rare disorder of the central nervous system caused by a de novo mutation in the glial fibrillary acidic protein (GFAP) gene. Unlike the much more common infantile form, the juvenile form is slowly progressive with bulbar, pyramidal and cerebellar signs. Herein, we report a 9-year old Japanese girl suffering from frequent vomiting, slurred speech and truncal ataxia. Juvenile Alexander disease was diagnosed by genetic analysis, which detected a novel GFAP mutation, D360V. We also describe our clinical success in treating this patient with thyrotropin releasing hormone (TRH). (c) 2006 Elsevier B.V. All rights reserved.
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