期刊
MAGNETIC RESONANCE IN MEDICINE
卷 56, 期 5, 页码 953-957出版社
WILEY
DOI: 10.1002/mrm.21068
关键词
PCr/TCr; magnetic resonance spectroscopy; in vivo; creatine supplementation; creatine turnover
The feasibility of a novel method for the noninvasive and local assessment of creatine (Cr) and phosphocreatine (PCr) dynamics in human skeletal muscle based on C-13 magnetic resonance (MR) spectroscopy is presented. A high dose of Cr, labeled the guanidino C-4 position with C-13 11 % enrichment, was administered orally to a human subject for 5 days. Using a surface Coll, 13C MR spectra of the lower leg were acquired on a 1.5T MR system at regular time intervals during and after Cr supple-mentation. An almost twofold increase in the intensities of the resolved PCr and Cr C-13-4 signals was observed during this period. The slow decrease in these signals to normal values after supplementation reflects the slow daily turnover of Cr. The PCr/Cr ratio did not appear to change over the whole measurement period. During exercise of the leg, reversible changes in PCr and Cr signals were observed, reflecting conversion by the Cr kinase reaction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据