期刊
INFECTION AND IMMUNITY
卷 74, 期 11, 页码 6496-6500出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00806-06
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The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.
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