期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1761, 期 11, 页码 1391-1399出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2006.09.011
关键词
phospholipase A2; PLB gene; Cryptcoccus neoformans; Aspergillus fumigatus; Candida albicans
资金
- NIDCR NIH HHS [P01 DE016839, P01 DE16839, R21 DE014705] Funding Source: Medline
As saprophytes or disease causing microorganisms, fungi acquire nutrients from dead organic material or living host organisms. Lipids as structural components of cell membranes and storage compartments play an important role as energy-rich food source. In recent years, it also has become clear that lipids have a wide range of bioactive properties including signal transduction and cell to cell communication. Thus, it is not surprising that fungi possess a broad range of hydrolytic enzymes that attack neutral lipids and phospholipids. Especially during infection of a mammalian host, phospholipase A(2) (PLA(2)) enzymes released by fungi could play important roles not only for nutrient acquisition and tissue invasion, but for intricate modulation of the host's immune response. Sequencing of fungal genomes has revealed a wide range of genes encoding PLA2 activities in fungi. We are just beginning to become aware of the significance these enzymes could have for the fungal cells and their interaction with the host. (c) 2006 Elsevier B.V. All rights reserved.
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