期刊
CLINICAL NEUROPHYSIOLOGY
卷 117, 期 11, 页码 2549-2563出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2006.08.003
关键词
attention; electrophysiology; event-related potentials; event-related oscillations; perception; stimulus salience
资金
- NIMH NIH HHS [R03 MH064466-01, MH 64466] Funding Source: Medline
Objective: Stimulus-driven salience is determined involuntarily, and by the physical properties of a stimulus. It has recently been theorized that neural coding of this variable involves oscillatory activity within cortical neuron populations at beta frequencies. This was tested here through experimental manipulation of inter-stimulus interval (ISI). Methods: Non-invasive neurophysiological measures of event-related gamma (30-50 Hz) and beta (12-20 Hz) activity were estimated from scalp-recorded evoked potentials. Stimuli were presented in a standard paired-stimulus sensory gating paradigm, where the S1 (conditioning) stimulus was conceptualized as long-ISI, or high salience, and the S2 (test) stimulus as short-ISI, or low salience. Three separate studies were conducted: auditory stimuli only (N = 20 participants), somatosensory stimuli only (N = 20), and a cross-modal study for which auditory and somatosensory stimuli were mixed (N = 40). Results: Early (20-150 ms) stimulus-evoked beta activity was more sensitive to ISI than temporally-overlapping gamma-band activity, and this effect was seen in both auditory and somatosensory studies. In the cross-modal study, beta activity was significantly modulated by the similarity (or dissimilarity) of stimuli separated by a short ISI (0.5 s); a significant cross-modal gating effect was nevertheless detected. Conclusions: With regard to the early sensory-evoked response recorded from the scalp, the interval between identical stimuli especially modulates beta oscillatory activity. Significance: This is consistent with developing theories regarding the different roles of tempo rally-overlapping oscillatory activity within cortical neuron populations at gamma and beta frequencies, particularly the claim that the latter is related to stimulus-driven salience. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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