期刊
MRS BULLETIN
卷 31, 期 11, 页码 881-886出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrs2006.207
关键词
crystal growth; morphology; nucleation; particle
The en engineering of particles with customized properties optimized for dosage form manufacture (tablet, capsule, ointment, etc.) has long been a goal of the pharmaceutical industry. Particles can be designed through modification in the size, e of the solids. The most common approach in morphology and packing arrangement achieving this is through crystallization. In this bottom-up process, the two main steps, nucleation and crystal growth, both play a decisive role in shaping the quality of the final crystallin product. In this review, the role of nucleation and crystal growth in conrotrolling particle properties is discussed, and examples are provided that demonstrate the variation in solid-state properties as a function of size, habit (morphology), and internal structure of the particles. In addition, the role of particle properties in product performance and dosage form development of pharmaceuticals is also discussed.
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