期刊
MOLECULAR CARCINOGENESIS
卷 45, 期 11, 页码 871-880出版社
WILEY-LISS
DOI: 10.1002/mc.20248
关键词
vascular smooth muscle cells; cell-cell interactions; motility; PDGF; NRP-1; breast tumor cells
资金
- NCI NIH HHS [CA87680] Funding Source: Medline
- NCRR NIH HHS [1 P20 RR15563] Funding Source: Medline
Motility of vascular smooth muscle cells (SMCs) is an essential step for both normal and pathologic angiogenesis. We report here that breast tumor cells, such as MCF-7 and MDA-MB-231, can modulate this SMC migration. We present evidence that the tumor cell-derived platelet-derived growth factor (PDGF) is the key regulator of vascular SMCs motility induced by breast cancer cells. PDGF significantly upregulates neuropilin-1 (NRP-1) mRNA expression and protein production in aortic smooth muscle cells (AOSMCs) and depletion of NRP-1 production by AOSMCs with specific short hairpin RNA (shRNA) prevents the PDGF-dependent migration of vascular SMCs. Moreover, we demonstrate that PDGF physically interacts with NRP-1. We propose that tumor-derived PDGF and NRP-1 of AOSMCs function as a relay system that promotes motility of vascular SMCs. (c) 2006 Wiley-Liss, Inc.
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