期刊
CELL CYCLE
卷 5, 期 21, 页码 2440-2442出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.5.21.3428
关键词
cyclin D1; migration; TSP-1; Rho; ROCK
类别
Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.
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