期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 63, 期 22, 页码 2584-2596出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-006-6085-8
关键词
transforming growth factor-beta; signaling pathways; heart tissues; therapeutic options
Transforming growth factor (TGF-beta) is a multifunctional peptide growth factor that has an important role in the regulation of cell growth, differentiation, and repair in a variety of tissues. In mammals, the cytokine has three isoforms, TGF-beta 1, TGF-beta 2, and TGF-beta 3. TGF-beta 1 is up-regulated by Ang II and induction of TGF-beta 1 causes cardiac fibrosis. The stimulus that triggers the expression of TGF-beta 1 may be repeated causing continual injury, which is associated with an increase in the activity of Ang II in heart tissue. The interplay between Ang II and TGF-beta 1 causes continued activation that may result in chronic hypertension and progressive myocardial fibrosis, leading to heart failure. The regulation of TGF-beta 1 secretion and action involves complex transcriptional events. Overproduction of TGF-beta 1 underlies tissue fibrosis. Understanding the actions and signaling transduction of TGF-beta could lead to the development of therapeutic options that may be effective in inhibiting myocardial fibrosis triggered by TGF-beta 1 in heart failure.
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