期刊
VIRUS RESEARCH
卷 121, 期 2, 页码 220-222出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2006.04.009
关键词
vaginal microbicides; nonoxynol-9; human papillomavirus; HIV
类别
This study investigated the effectiveness of a nonoxynol-9 (52.5 mg, 3.5%), vaginal gel (Advantage S), in the prevention of human papillomavirus (HPV) infection in female sex workers. We showed by HPV DNA determination in cervico-vaginal rinses a significant increase in multiple (> 1) HPV infection in HIV-1 seropositive women compared with HIV-1 seronegative women (OR 4.0, 95% CI 1.3-11.9). We also demonstrated a significant increase in multiple HPV infections in HIV-1 seronegative women using nonoxynol-9 compared with HIV-1 seronegative women using placebo (OR 3.5 95% CI 1.0-11.8). We conclude that the use of nonoxynol-9 did not prevent genital HPV infection and could increase the virus' ability to infect or persist. (c) 2006 Published by Elsevier B.V.
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