期刊
JOURNAL OF DENTAL RESEARCH
卷 85, 期 11, 页码 966-979出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910608501101
关键词
stem cells; tissue engineering; biomaterials; wound healing; regenerative medicine
资金
- NIBIB NIH HHS [R01 EB002332, EB02332] Funding Source: Medline
- NIDCR NIH HHS [T32 DE007057, R01 DE013028, DE13397, RC2 DE020767, R21 DE016619-02, R01 DE015391, R01 DE013964, DE14526, DE13194, R01 DE013397, R01 DE013964-01, R01 DE012462, R01 DE015384-04, R01 DE015384, R21 DE016619, DE012462, DE13964, DE15384, DE007057, DE013835, DE13028, R01 DE013194, R01 DE016129, R01 DE013397-07, R01 DE013835, R29 DE012462, DE016129, DE013608, RC2 DE020767-02, R01 DE013608, DE16619, R01 DE016530, DE016530, R01 DE014526] Funding Source: Medline
Craniofacial tissue engineering promises the regeneration or de novo formation of dental, oral, and craniofacial structures lost to congenital anomalies, trauma, and diseases. Virtually all craniofacial structures are derivatives of mesenchymal cells. Mesenchymal stem cells are the offspring of mesenchymal cells following asymmetrical division, and reside in various craniofacial structures in the adult. Cells with characteristics of adult stem cells have been isolated from the dental pulp, the deciduous tooth, and the periodontium. Several craniofacial structures-such as the mandibular condyle, calvarial bone, cranial suture, and subcutaneous adipose tissue-have been engineered from mesenchymal stem cells, growth factor, and/or gene therapy approaches. As a departure from the reliance of current clinical practice on durable materials such as amalgam, composites, and metallic alloys, biological therapies utilize mesenchymal stem cells, delivered or internally recruited, to generate craniofacial structures in temporary scaffolding biomaterials. Craniofacial tissue engineering is likely to be realized in the foreseeable future, and represents an opportunity that dentistry cannot afford to miss.
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